Classics in Total Synthesis
by E. J. Sorensen, K. C. Nicolaou
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Book Summary Information
Author: E. J. Sorensen, K. C. NicolaouEdition: Hardcover
Audio: English (Unknown); English (Original Language); English (Published)
Published: 1996-01-31
ISBN: 3527292845
Number of pages: 798
Publisher: Wiley-VCH
Book Reviews of Classics in Total Synthesis
Book Review: This Could Be The Only Synthesis Book You Need...
Summary: 5 Stars
A graduate student strongly recommended me to get this book and start reading. At first intimidated by the complex synthesis steps and unfamiliar reagents, the Nicolaou synthesis book is a must read for organic students and chemists. Unlike "The Logic of Chemical Synthesis" (no doubt is also well-written), Nicolaou's "Classics in Total Synthesis" is a pictorial account of some of the representative syntheses of natural products. The detailed, well-written text discusses total synthesis work of chemists such as Heathcock, Corey, Evans, and Nicolaou himself. Each synthesis is preceded with the historical background and significance. A detailed synthetic scheme is included with detailed discussion of each intemediate and inidvidual step. Reader will surely learn a great deal by working through each synthetic step with a pencil and paper. While most advanced organic texts discuss the typical traditional methods in synthetic chemistry, Nicolaou discusses practical approach to synthesizing complex stereospecific compounds. Corey's "The Logic of Chemical Syntheses" might have the similar scope in organic synthesis, yet Nicolaou will be more reader-friendly especially for beginning students in organic synthesis. Nicolaou presents not only the tactics of the subject, it also brings out the beauty of the art of total synthesis. A good read!
Summary of Classics in Total Synthesis
This book is a must for every synthetic chemist. With didactic skill and clarity, K. C. Nicolaou and E. Sorensen present the most remarkable and ingenious total syntheses from outstanding synthetic organic chemists.To make the complex strategies more accessible, especially to the novice, each total synthesis is analyzed retrosynthetically. The authors then carefully explain each synthetic step and give hints on alternative methods and potential pitfalls. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.
Special emphasis is placed on the skillful use of graphics and schemes: Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text. For easy reference, key intermediates are also shown in the margins.
Graduate students and researchers alike will find this book a gold mine of useful information essential for their daily work. Every synthetic organic chemist will want to have a copy on his or her desk.
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