Genomes
by Terence A. Brown

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Book Reviews of Genomes

Book Review: Good overview of modern genetics
Summary: 4 Stars

Some of the more interesting discussions in the book include: 1. The C-value paradox: The correlation between the complexity of an organism and the size of its genome is explained by a space optimization argument, i.e. the genomes of simpler organisms conserve space by packing the genes closer together. 2. Using DNA markers versus gene markers for genetic mapping. 3. Single nucleotide polymorphisms, oligonucleotide hybridization analysis, and their use in DNA chip technology and dynamic allele-specific hybridization. 4. The need for physical mapping techniques and the discussion on the discrepancies between genetic and physical maps of S. cerevisiae chromosome III. 5. The use of orthogonal field alternation gel electrophoresis to separate molecules of more than 50kb in length. 6. Rapid sequence acquisition strategies, such as expressed sequence tags and sequence skimming. 7. The ethicial ramifications of the Human Genome Project. 8. The difficulty of existing software programs to assist in the location of exon-intron boundaries. 9. Homology searching and analysis. 10. The telomere and the role of telomeric proteins in capping chromosome ends. 11. The location of genes and the isochore model of genome organization. 12. The role of extra chromosomal genes in explaining inheritance patterns of some phenotypes in fungi, yeasts, and algae. 13. The (unanswered) questions as to why organelle genomes cannot be transported through the membranes that surround mitochondira and chloroplasts. 14. The discovery in the 1980s that DNA transfer from organelle to nucleus still occurs and the role of promiscuous DNA. 15. The experimental evidence that genes are made of DNA. 16. The role of bacterial RNA polymerase as a 'sliding clamp'. 17. The three-dimensional structure of tRNA. 18. Ribosome frameshifting. 19. Transient changes in genome activity. 20. Rearrangements of genomes 21. Genome regulation by feedback loops. 22. The genetic basis of flower development. 23. Mutations and recombination. Readers interested in genetic algorithms will appreciate this discussion. 24. The experimental detection of mutations. 25. Adapative mutations in E. coli. Because of its challenge to the current paradigm of evolution, this discussion was particularly interesting. 26. Evidence for ancient genome duplication and molecular phylogenetics.

Summary of Genomes

Biochemistry Books

• Subjects > Science & Math > Biological Sciences > Biochemistry
• Biology > Microbiology
• Molecular Biology
• Evolution > Genetics